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Targeted Allele Detail
Symbol: Gata1tm1.1Yen
Name: GATA binding protein 1; targeted mutation 1.1, Hsin-Fang Yang-Yen
MGI ID: MGI:5521597
Synonyms: GATA-1S26E
Gene: Gata1  Location: ChrX:7959260-7976663 bp, - strand  Genetic Position: ChrX, 3.59 cM, cytoband A2
Germline Transmission:  Earliest citation of germline transmission: J:200716
Parent Cell Line:  R1 (ES Cell)
Strain of Origin:  (129X1/SvJ x 129S1/Sv)F1-Kitl+
Allele Type:    Targeted (Not Applicable)
Mutations:    Insertion, Nucleotide substitutions
Mutation detailsExon 2 was replaced with a modified exon 2 in which nucleotide substitutions (TCA to GAG) result in the amino acid susbtitution of glutamic acid for serine at position 26 (S26E). This mutation mimics phosphorylation at this site. Cre-mediated recombination removed the floxed neomycin resistance cassette inserted downstream of the modified exon 2. (J:200716)
Generation of the Gata1tm1.1Yen or Gata1tm2.1Yen alleles
View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Gata1 Mutation:  42 strains or lines available
Original:  J:200716 Lin KR, et al., Constitutive phosphorylation of GATA-1 at serine(2)(6) attenuates the colony-forming activity of erythrocyte-committed progenitors. PLoS One. 2013;8(5):e64269
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
MGI 6.14
The Jackson Laboratory