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Bcl6tm1.1Dent
Targeted Allele Detail
Nomenclature
Symbol: Bcl6tm1.1Dent
Name: B cell leukemia/lymphoma 6; targeted mutation 1.1, Alexander Dent
MGI ID: MGI:5518542
Synonyms: Bcl6fl
Gene: Bcl6  Location: Chr16:23783802-23807602 bp, - strand  Genetic Position: Chr16, 15.26 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:202372
Parent Cell Line:  CCE/EK.CCE (ES Cell)
Strain of Origin:  129S/SvEv-Gpi1c
Mutation
description
Allele Type:    Targeted (Conditional ready, No functional change)
Mutation:    Insertion
 
Mutation detailsA targeting vector was designed to insert a single loxP site upstream of exon 7, and a loxP-flanked neomycin resistance (neo) cassette downstream of exon 9. Exons 7-9 encode the zinc finger domain. The neo selection cassette was subsequently removed from properly targeted mice by crossing to transgenic mice carrying Tg(EIIa-cre)C5379Lmgd. (J:101977, J:202372)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Structures Affected by this Mutation: 1 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Bcl6 Mutation:  33 strains or lines available
References
Original:  J:202372 Hollister K, et al., Insights into the role of Bcl6 in follicular Th cells using a new conditional mutant mouse model. J Immunol. 2013 Oct 1;191(7):3705-11
All:  34 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
09/07/2021
MGI 6.17
The Jackson Laboratory