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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Bcl6tm1.1Dent
targeted mutation 1.1, Alexander Dent
MGI:5518542
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Bcl6tm1.1Dent/Bcl6tm1.1Dent involves: 129S/SvEv * C57BL/6 * FVB/N MGI:5518549
cn2
 		Bcl6tm1.1Dent/Bcl6tm1.1Dent
Tg(Cd4-cre)1Cwi/0 		involves: 129S/SvEv * C57BL/6 * DBA/2 * FVB/N MGI:5518550


Genotype
MGI:5518549
hm1
Allelic
Composition		 Bcl6tm1.1Dent/Bcl6tm1.1Dent
Genetic
Background		 involves: 129S/SvEv * C57BL/6 * FVB/N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Bcl6tm1.1Dent mutation (3 available); any Bcl6 mutation (55 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
normal phenotype
no abnormal phenotype detected ( J:202372 )
• mice appear normal and produce normal B and T cell responses following immunization




Genotype
MGI:5518550
cn2
Allelic
Composition		 Bcl6tm1.1Dent/Bcl6tm1.1Dent
Tg(Cd4-cre)1Cwi/0
Genetic
Background		 involves: 129S/SvEv * C57BL/6 * DBA/2 * FVB/N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Bcl6tm1.1Dent mutation (3 available); any Bcl6 mutation (55 available)
Tg(Cd4-cre)1Cwi mutation (10 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
abnormal T follicular helper cell differentiation ( J:202372 )
• decrease in IL4 secretion from CD4 T cells isolated from SRBC-immunized mice as compared to control
• increase in IL10 secretion (20 fold) from activated CD4 T cells as compared to control
• increase in apoptotic markers (caspase 3 and annexin V) in PD-1high follicular T helper cells from spleen at 10 days post-immunization
decreased germinal center B cell number ( J:202372 )
• analysis of spleens at 10 days post-immunization with sheep red blood cells (SRBC) reveals almost complete loss of Fas+ GL7+PNA+ germinal center B cells
decreased T follicular helper cell number ( J:202372 )
• analysis of spleens at 10 days post-immunization with sheep red blood cells (SRBC) reveals almost complete loss of CXCR5+ ICOS+PD-1high follicular T helper cells
decreased IgG level ( J:202372 )
• SRBC specific IgG titers post-immunization are 5 fold lower than controls
increased interleukin-10 secretion ( J:202372 )
• increase in IL10 secretion (20 fold) from activated CD4 T cells as compared to control
decreased interleukin-4 secretion ( J:202372 )
• decrease in IL4 secretion from CD4 T cells isolated from SRBC-immunized mice as compared to control

hematopoietic system
abnormal T follicular helper cell differentiation ( J:202372 )
• decrease in IL4 secretion from CD4 T cells isolated from SRBC-immunized mice as compared to control
• increase in IL10 secretion (20 fold) from activated CD4 T cells as compared to control
• increase in apoptotic markers (caspase 3 and annexin V) in PD-1high follicular T helper cells from spleen at 10 days post-immunization
decreased germinal center B cell number ( J:202372 )
• analysis of spleens at 10 days post-immunization with sheep red blood cells (SRBC) reveals almost complete loss of Fas+ GL7+PNA+ germinal center B cells
decreased T follicular helper cell number ( J:202372 )
• analysis of spleens at 10 days post-immunization with sheep red blood cells (SRBC) reveals almost complete loss of CXCR5+ ICOS+PD-1high follicular T helper cells
decreased IgG level ( J:202372 )
• SRBC specific IgG titers post-immunization are 5 fold lower than controls




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
04/23/2024
MGI 6.23 		The Jackson Laboratory