Dact3^tm1.1Yegc
Targeted Allele Detail

Summary

• Symbol: Dact3^tm1.1Yegc
• Name: dishevelled-binding antagonist of beta-catenin 3; targeted mutation 1.1, Ye-Guang Chen
• MGI ID: MGI:5515616
• Gene: Dact3 Location: Chr7:16609242-16621226 bp, + strand Genetic Position: Chr7, 9.15 cM
• Alliance: Dact3^tm1.1Yegc page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:199623
• Parent Cell Line: B6/BLU (ES Cell)
• Strain of Origin: C57BL/6NTac-Tg(HBB-lacZ)ALey/Ley

Mutation description

Allele Type: Targeted (Null/knockout) Mutations: Insertion, Intragenic deletion Mutation details: A loxP site was inserted upstream of exon 2. An FRT-flanked neomycin resistance cassette with a 3' loxP site was inserted downstream of exon 3. Cre-mediated recombination removed exon 2, exon 3 and the neomycin resistance cassette. Western blot analysis confirmed the absence of protein expression in mouse embryonic fibroblasts. (J:199623)

Generation of the Dact3^tm1.1Yegc allele

Expression

In Structures Affected by this Mutation:

3 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Dact3 Mutation: 21 strains or lines available

References

• Original: J:199623 Xue H, et al., Disruption of the Dapper3 gene aggravates ureteral obstruction-mediated renal fibrosis by amplifying Wnt/beta-catenin signaling. J Biol Chem. 2013 May 24;288(21):15006-14
• All: 1 reference(s)