Phenotypes associated with this allele

• Allele Symbol: Dact3^tm1.1Yegc
• Allele Name: targeted mutation 1.1, Ye-Guang Chen
• Allele ID: MGI:5515616
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Dact3^tm1.1Yegc/Dact3^tm1.1Yegc	involves: C57BL/6 * FVB/N	MGI:5515620

Genotype
MGI:5515620

hm1

• Allelic Composition: Dact3^tm1.1Yegc/Dact3^tm1.1Yegc
• Genetic Background: involves: C57BL/6 * FVB/N

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

renal/urinary system

abnormal kidney morphology ( J:199623 )

• following unilateral uretal obstruction, mice exhibit enhanced myofibroblast activation, epithelial to mesenchymal transition and matrix production, as determined by marker expression, compared with wild-type mice

abnormal renal tubule epithelium morphology ( J:199623 )

• primary cultured renal tubular cells treated with Wnt3a exhibit increased epithelial to mesenchymal cell transition, as determined by marker expression, compared with wild-type cells

renal interstitial fibrosis ( J:199623 )

• aggravated following unilateral uretal obstruction

growth/size/body

decreased body weight ( J:199623 )

• until 17 weeks in female mice

• in male mice from 17 weeks on

postnatal growth retardation ( J:199623 )

• mild in adults, especially males

homeostasis/metabolism

homeostasis/metabolism phenotype ( J:199623 )

N • mice exhibit normal lipid metabolism

increased susceptibility to injury ( J:199623 )

• following unilateral uretal obstruction, mice exhibit enhanced myofibroblast activation, epithelial to mesenchymal transition and matrix production, as determined by marker expression, and aggravated renal interstitial fibrosis compared with wild-type mice