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Psmb11tm1(Psmb8)Khog
Targeted Allele Detail
Nomenclature
Symbol: Psmb11tm1(Psmb8)Khog
Name: proteasome (prosome, macropain) subunit, beta type, 11; targeted mutation 1, Kristin Hogquist
MGI ID: MGI:5514401
Synonyms: beta5t-
Gene: Psmb11  Location: Chr14:54625310-54629556 bp, + strand  Genetic Position: Chr14, 27.87 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:196156
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  C57BL/6
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsA cDNA for Psmb8 with a FLAG tag and floxed neomycin resistance cassette replaced the coding sequence. Western blot analysis confirmed the absence of protein expression in the thymus. (J:196156)
Generation of the Psmb11tm1(Psmb8)Khog and Psmb11tm1.1(Psmb8)Khog alleles
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Psmb11 Mutation:  4 strains or lines available
References
Original:  J:196156 Xing Y, et al., Thymoproteasome subunit-beta5T generates peptide-MHC complexes specialized for positive selection. Proc Natl Acad Sci U S A. 2013 Apr 23;110(17):6979-84
All:  2 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
10/08/2019
MGI 6.14
The Jackson Laboratory