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Targeted Allele Detail
Symbol: Psmb11tm1(Psmb8)Khog
Name: proteasome (prosome, macropain) subunit, beta type, 11; targeted mutation 1, Kristin Hogquist
MGI ID: MGI:5514401
Synonyms: beta5t-
Gene: Psmb11  Location: Chr14:54625310-54629556 bp, + strand  Genetic Position: Chr14, 27.87 cM
Germline Transmission:  Earliest citation of germline transmission: J:196156
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  C57BL/6
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
Mutation detailsA cDNA for Psmb8 with a FLAG tag and floxed neomycin resistance cassette replaced the coding sequence. Western blot analysis confirmed the absence of protein expression in the thymus. (J:196156)
Generation of the Psmb11tm1(Psmb8)Khog and Psmb11tm1.1(Psmb8)Khog alleles
View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Psmb11 Mutation:  4 strains or lines available
Original:  J:196156 Xing Y, et al., Thymoproteasome subunit-beta5T generates peptide-MHC complexes specialized for positive selection. Proc Natl Acad Sci U S A. 2013 Apr 23;110(17):6979-84
All:  2 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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MGI 6.14
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