Mir21atm1.1Zqy
Targeted Allele Detail
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Symbol: |
Mir21atm1.1Zqy |
Name: |
microRNA 21a; targeted mutation 1.1, Zhi-Qiang Yan |
MGI ID: |
MGI:5514060 |
Synonyms: |
miR21 flox |
Gene: |
Mir21a Location: Chr11:86474893-86474984 bp, - strand Genetic Position: Chr11, 51.82 cM
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Alliance: |
Mir21atm1.1Zqy page
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Decrease in elastin and collagen content in Mir21atm1.1Zqy/Mir21atm1.1Zqy Tg(Tek-cre)12Flv/0 aorta
Show the 2 phenotype image(s) involving this allele.
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Germline Transmission: |
Earliest citation of germline transmission:
J:199907
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Parent Cell Line: |
Not Specified (ES Cell)
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Strain of Origin: |
129S/SvEv
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Allele Type: |
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Targeted (Conditional ready, No functional change) |
Mutation: |
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Insertion
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Mutation details: An FRT-flanked neomycin resistance cassette with a 3' loxP site was inserted upstream of exon 1. An additional loxP site was inserted downstream of exon 1. Flp-mediated recombination removed the neomycin resistance cassette and left exon 1 floxed.
(J:199907)
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Generation of the Mir21atm1.1Zqy allele |
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View phenotypes and curated references for all genotypes (concatenated display).
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Mouse strains and cell lines
available from the International Mouse Strain Resource
(IMSR) |
Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available
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Carrying any Mir21a Mutation: |
8 strains or lines available
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Original: |
J:199907 Zhang XY, et al., Induction of thoracic aortic remodeling by endothelial-specific deletion of microRNA-21 in mice. PLoS One. 2013;8(3):e59002 |
All: |
1 reference(s) |
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