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Lamc1tm1.2Strl
Targeted Allele Detail
Nomenclature
Symbol: Lamc1tm1.2Strl
Name: laminin, gamma 1; targeted mutation 1.2, Sidney Strickland
MGI ID: MGI:5504479
Gene: Lamc1  Location: Chr1:153218922-153332786 bp, - strand  Genetic Position: Chr1, 65.3 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:199683
Parent Cell Line:  E14 (ES Cell)
Strain of Origin:  129P2/OlaHsd
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsExon 2 was flanked by single loxP sites. An frt flanked neomycin resistance cassette was inserted upstream of the floxed region, in intron 1. Cre-mediated recombination removed exon 2. (J:199683)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Structures Affected by this Mutation: 3 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Lamc1 Mutation:  114 strains or lines available
References
Original:  J:199683 McKee KK, et al., Schwann cell myelination requires integration of laminin activities. J Cell Sci. 2012 Oct 1;125(Pt 19):4609-19
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
02/11/2020
MGI 6.14
The Jackson Laboratory