Phenotypes associated with this allele

• Allele Symbol: Lamc1^tm1.2Strl
• Allele Name: targeted mutation 1.2, Sidney Strickland
• Allele ID: MGI:5504479
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
ht1	Lamc1^tm1Strl/Lamc1^tm1.2Strl	either: (involves: 129P2/OlaHsd * C57BL/6 * CBA) or (involves: 129P2/OlaHsd * 129S6/SvEvTac * C57BL/6 * CBA)	MGI:5504483

Genotype
MGI:5504483

ht1

• Allelic Composition: Lamc1^tm1Strl/Lamc1^tm1.2Strl
• Genetic Background: either: (involves: 129P2/OlaHsd * C57BL/6 * CBA) or (involves: 129P2/OlaHsd * 129S6/SvEvTac * C57BL/6 * CBA)

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

muscle

abnormal quadriceps morphology ( J:199683 )

• with scattered small myotubues and central nuclei in the absence of obvious endomysial fibrosis but an increase in interstitial collagen fibrils

decreased skeletal muscle fiber diameter ( J:199683 )

centrally nucleated skeletal muscle fibers ( J:199683 )

• in the quadriceps

decreased skeletal muscle mass ( J:199683 )

• in the lower back and hindlimbs

skeletal muscle fiber atrophy ( J:199683 )

• smaller muscle diameter

nervous system

increased Schwann cell number ( J:199683 )

• 7-fold increase in Schwann cells that do not myelinate

demyelination ( J:199683 )

• areas of amyelination with 2-fold reduction in myelinated axons and near-complete absence of enveloped axons and naked axons

behavior/neurological

limb grasping ( J:199683 )

• slightly tremulous and retracted inward limbs when suspended by tail

paraparesis ( J:199683 )

• with difficulty in ambulation

cellular

increased Schwann cell number ( J:199683 )

• 7-fold increase in Schwann cells that do not myelinate

abnormal basement membrane morphology ( J:199683 )

• 2-fold decrease of Schwann cell lamellipodial processesed basement membrane

limbs/digits/tail

abnormal quadriceps morphology ( J:199683 )

• with scattered small myotubues and central nuclei in the absence of obvious endomysial fibrosis but an increase in interstitial collagen fibrils