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Sec24ctm1c(EUCOMM)Wtsi
Targeted Allele Detail
Nomenclature
Symbol: Sec24ctm1c(EUCOMM)Wtsi
Name: Sec24 related gene family, member C (S. cerevisiae); targeted mutation 1c, Wellcome Trust Sanger Institute
MGI ID: MGI:5501469
Synonyms: Sec24cFL
Gene: Sec24c  Location: Chr14:20674308-20694852 bp, + strand  Genetic Position: Chr14, 11.53 cM
Mutation
origin
Mutant Cell Line:  EPD0241_2_A11
Germline Transmission:  Earliest citation of germline transmission: J:232065
Parent Cell Line:  JM8.N4 (ES Cell)
Strain of Origin:  C57BL/6N
Project Collection: EUCOMM
Mutation
description
Allele Type:    Targeted (Conditional ready)
Mutation:    Insertion     Vector: L1L2_Pgk_P
 
Mutation detailsThe L1L2_Pgk_P cassette was inserted at position 20679037 of Chromosome 14 upstream of exon 3. The cassette is composed of an FRT site followed by lacZ sequence and a loxP site. This first loxP site is followed by neomycin resistance gene under the control of the PGK promoter, SV40 polyA, a second FRT site and a second loxP site. A third loxP site is inserted downstream of exon 3 at position 20679926. A "conditional ready" (floxed) allele was created by flp recombinase expression in mice, deleting the lacZ seqences and neomycin selection cassette, leaving exon 3 flanked by loxP sites. (J:232065)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Sec24c Mutation:  31 strains or lines available
Notes
Cell line EPD0241_2_A11 was successfully used to make chimeric mice. Germline transmission was accomplished. J:232065
References
Original:  J:232065 Adams EJ, et al., Mammalian COPII coat component SEC24C is required for embryonic development in mice. J Biol Chem. 2014 Jul 25;289(30):20858-70
All:  2 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
04/13/2021
MGI 6.16
The Jackson Laboratory