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Targeted Allele Detail
Symbol: Nkx6-1tm1.1Msan
Name: NK6 homeobox 1; targeted mutation 1.1, Maike Sander
MGI ID: MGI:5501129
Synonyms: Nkx6.1flox
Gene: Nkx6-1  Location: Chr5:101807050-101812577 bp, - strand  Genetic Position: Chr5, 48.84 cM
Germline Transmission:  Earliest citation of germline transmission: J:195153
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  129S6/SvEvTac
Allele Type:    Targeted (Conditional ready, No functional change)
Mutation:    Insertion
Mutation detailsA loxP site was inserted upstream of exon 2. An FRT-flanked neomycin resistance (neo) cassette with a 3' loxP site was inserted downstream of exon 2. Flp-mediated recombination removed the neo cassette and left exon 2 floxed. (J:195153)
Generation of the Nkx6-1tm1.1Msan and Nkx6-1tm1.2Msan alleles
View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Nkx6-1 Mutation:  3 strains or lines available
Original:  J:195153 Schaffer AE, et al., Nkx6.1 controls a gene regulatory network required for establishing and maintaining pancreatic Beta cell identity. PLoS Genet. 2013 Jan;9(1):e1003274
All:  4 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
MGI 6.17
The Jackson Laboratory