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Nkx6-1tm1.1Msan
Targeted Allele Detail
Nomenclature
Symbol: Nkx6-1tm1.1Msan
Name: NK6 homeobox 1; targeted mutation 1.1, Maike Sander
MGI ID: MGI:5501129
Synonyms: Nkx6.1flox
Gene: Nkx6-1  Location: Chr5:101659184-101664711 bp, - strand  Genetic Position: Chr5, 48.84 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:195153
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  129S6/SvEvTac
Mutation
description
Allele Type:    Targeted (Conditional ready, No functional change)
Mutation:    Insertion
 
Mutation detailsA loxP site was inserted upstream of exon 2. An FRT-flanked neomycin resistance (neo) cassette with a 3' loxP site was inserted downstream of exon 2. Flp-mediated recombination removed the neo cassette and left exon 2 floxed. (J:195153)
Generation of the Nkx6-1tm1.1Msan and Nkx6-1tm1.2Msan alleles
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Nkx6-1 Mutation:  2 strains or lines available
References
Original:  J:195153 Schaffer AE, et al., Nkx6.1 controls a gene regulatory network required for establishing and maintaining pancreatic Beta cell identity. PLoS Genet. 2013 Jan;9(1):e1003274
All:  4 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
12/03/2019
MGI 6.14
The Jackson Laboratory