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Arhgef26tm1.1Kbur
Targeted Allele Detail
Nomenclature
Symbol: Arhgef26tm1.1Kbur
Name: Rho guanine nucleotide exchange factor (GEF) 26; targeted mutation 1.1, Keith Burridge
MGI ID: MGI:5500046
Gene: Arhgef26  Location: Chr3:62338777-62462221 bp, + strand  Genetic Position: Chr3, 29.97 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:195919
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  Not Specified
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsA loxP site was inserted upstream of exon 4. An FRT-flanked neomycin resistance (neo) cassette with a 3' loxP site was inserted downstream of exon 5. Cre-mediated recombination removed exon 4, exon 5 and the neo cassette. Western blot analysis confirmed the absence of protein expression in the liver, lung and brain. (J:195919)
Generation of the Arhgef26tm1.1Kbur allele
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Arhgef26 Mutation:  7 strains or lines available
References
Original:  J:195919 Samson T, et al., The guanine-nucleotide exchange factor SGEF plays a crucial role in the formation of atherosclerosis. PLoS One. 2013;8(1):e55202
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
05/26/2020
MGI 6.15
The Jackson Laboratory