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Targeted Allele Detail
Symbol: Arhgef26tm1.1Kbur
Name: Rho guanine nucleotide exchange factor (GEF) 26; targeted mutation 1.1, Keith Burridge
MGI ID: MGI:5500046
Gene: Arhgef26  Location: Chr3:62338777-62462221 bp, + strand  Genetic Position: Chr3, 29.97 cM
Germline Transmission:  Earliest citation of germline transmission: J:195919
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  Not Specified
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
Mutation detailsA loxP site was inserted upstream of exon 4. An FRT-flanked neomycin resistance (neo) cassette with a 3' loxP site was inserted downstream of exon 5. Cre-mediated recombination removed exon 4, exon 5 and the neo cassette. Western blot analysis confirmed the absence of protein expression in the liver, lung and brain. (J:195919)
Generation of the Arhgef26tm1.1Kbur allele
View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Arhgef26 Mutation:  7 strains or lines available
Original:  J:195919 Samson T, et al., The guanine-nucleotide exchange factor SGEF plays a crucial role in the formation of atherosclerosis. PLoS One. 2013;8(1):e55202
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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MGI 6.15
The Jackson Laboratory