Ctsktm1.1Rbar
Targeted Allele Detail
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Symbol: |
Ctsktm1.1Rbar |
Name: |
cathepsin K; targeted mutation 1.1, Roland Baron |
MGI ID: |
MGI:5492037 |
Synonyms: |
Ctskfl |
Gene: |
Ctsk Location: Chr3:95406567-95416673 bp, + strand Genetic Position: Chr3, 40.74 cM
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Alliance: |
Ctsktm1.1Rbar page
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Increase in cancellous bone mass in Ctsktm1.1Rbar/Ctsktm1.1Rbar Tg(Mx1-cre)1Cgn/0 and Ctsktm1.1Rbar/Ctsktm1.1Rbar Tg(Itgam-cre)AJva/0 mice
Show the 4 phenotype image(s) involving this allele.
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Germline Transmission: |
Earliest citation of germline transmission:
J:194492
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Parent Cell Line: |
Not Specified (ES Cell)
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Strain of Origin: |
Not Specified
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Allele Type: |
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Targeted (Conditional ready, No functional change) |
Mutation: |
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Insertion
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Mutation details: A loxP site was inserted upstream of exon 5. A floxed neo cassette was inserted downstream of exon 5. Cre-mediated recombination removed the neo cassette and left exon 5 floxed.
(J:194492)
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Generation of the Ctsktm1.1Rbar allele |
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View phenotypes and curated references for all genotypes (concatenated display).
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Mouse strains and cell lines
available from the International Mouse Strain Resource
(IMSR) |
Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available
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Carrying any Ctsk Mutation: |
29 strains or lines available
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Original: |
J:194492 Lotinun S, et al., Osteoclast-specific cathepsin K deletion stimulates S1P-dependent bone formation. J Clin Invest. 2013 Feb;123(2):666-81 |
All: |
2 reference(s) |
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