Heph^tm1.1Jdun
Targeted Allele Detail

Summary

• Symbol: Heph^tm1.1Jdun
• Name: hephaestin; targeted mutation 1.1, Joshua L Dunaief
• MGI ID: MGI:5490635
• Synonyms: Heph^F
• Gene: Heph Location: ChrX:95499042-95618091 bp, + strand Genetic Position: ChrX, 42.69 cM
• Alliance: Heph^tm1.1Jdun page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:196540
• Parent Cell Line: iTL IC1 (ES Cell)
• Strain of Origin: C57BL/6NTac

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: Exon 4 was floxed. Flp-mediated recombination removed the FRT-flanked neomycin resistance cassette inserted upstream of exon 4. (J:196540)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Heph Mutation: 10 strains or lines available

References

• Original: J:196540 Wolkow N, et al., Ferroxidase hephaestin's cell-autonomous role in the retinal pigment epithelium. Am J Pathol. 2012 Apr;180(4):1614-24
• All: 5 reference(s)