Dscam^3J
Spontaneous Allele Detail

Summary

• Symbol: Dscam^3J
• Name: DS cell adhesion molecule; 3 Jackson
• MGI ID: MGI:5488751
• Synonyms: DSCAM^R1018P, nm2122
• Gene: Dscam Location: Chr16:96392040-96971952 bp, - strand Genetic Position: Chr16, 57.02 cM, cytoband C
• Alliance: Dscam^3J page

Large dome shaped head, muscle stiffness and enlarged central and lateral ventricles in Dscam^3J/Dscam^3J mice

Show the 2 phenotype image(s) involving this allele.

Mutation origin

• Strain of Origin: C3SnSmn.Cg-Prkdc^scid/J

Mutation description

Allele Type: Spontaneous Mutation: Single point mutation Mutation details: A spontaneous G-to-C point mutation (C-to-G on forward strand) results in the amino acid substitution of arginine with proline at position 1018 (p.R1018P). Western blot analysis confirmed normal protein expression levels. (J:195831)

Single nucleotide substitution of proline for arginine at position 1018 in the Dscam^3J allele

Expression

In Structures Affected by this Mutation:

7 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Dscam Mutation: 105 strains or lines available

References

• Original: J:195831 Schramm RD, et al., A novel mouse Dscam mutation inhibits localization and shedding of DSCAM. PLoS One. 2012;7(12):e52652
• All: 2 reference(s)