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Targeted Allele Detail
Symbol: Ubr4tm1.1Ytkw
Name: ubiquitin protein ligase E3 component n-recognin 4; targeted mutation 1.1, Yong Tae Kwon
MGI ID: MGI:5487648
Gene: Ubr4  Location: Chr4:139380659-139489533 bp, + strand  Genetic Position: Chr4, 70.66 cM
Germline Transmission:  Earliest citation of germline transmission: J:196073
Parent Cell Line:  E14 (ES Cell)
Strain of Origin:  129P2/OlaHsd
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
Mutation detailsExons 36 - 42 were replaced with an IRES-tau-LacZ cassette and a floxed tACE-Cre-Neo cassette via homologous recombination. Cre mediated recombination removed the neo cassette. (J:196073)
View phenotypes and curated references for all genotypes (concatenated display).
In Mice Carrying this Mutation: 6 assay results
In Structures Affected by this Mutation: 1 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Ubr4 Mutation:  16 strains or lines available
Original:  J:196073 Tasaki T, et al., UBR box N-recognin-4 (UBR4), an N-recognin of the N-end rule pathway, and its role in yolk sac vascular development and autophagy. Proc Natl Acad Sci U S A. 2013 Mar 5;110(10):3800-5
All:  3 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
MGI 6.14
The Jackson Laboratory