Trpc5^tm1.1Lbi
Targeted Allele Detail

Summary

• Symbol: Trpc5^tm1.1Lbi
• Name: transient receptor potential cation channel, subfamily C, member 5; targeted mutation 1.1, Lutz Birnbaumer
• MGI ID: MGI:5474572
• Gene: Trpc5 Location: ChrX:143164667-143471176 bp, - strand Genetic Position: ChrX, 65.49 cM, cytoband F2
• Alliance: Trpc5^tm1.1Lbi page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:194590
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129S6/SvEvTac

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Exon 5 was floxed via homologous recombination. Cre mediated recombination removed exon 5. Absence of protein expression was confirmed by immunofluorescent staining of the hippocampal region of homozygous mice. (J:194590)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Trpc5 Mutation: 19 strains or lines available

References

• Original: J:194590 Phelan KD, et al., Canonical transient receptor channel 5 (TRPC5) and TRPC1/4 contribute to seizure and excitotoxicity by distinct cellular mechanisms. Mol Pharmacol. 2013 Feb;83(2):429-38
• All: 13 reference(s)