Phenotypes associated with this allele

• Allele Symbol: Trpc5^tm1.1Lbi
• Allele Name: targeted mutation 1.1, Lutz Birnbaumer
• Allele ID: MGI:5474572
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Trpc5^tm1.1Lbi/Trpc5^tm1.1Lbi	involves: 129S6/SvEvTac * C57BL/6 * CBA	MGI:5474573
ot2	Trpc5^tm1.1Lbi/Y	involves: 129S6/SvEvTac * C57BL/6 * CBA	MGI:5474574

Genotype
MGI:5474573

hm1

• Allelic Composition: Trpc5^tm1.1Lbi/Trpc5^tm1.1Lbi
• Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * CBA

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

behavior/neurological

behavior/neurological phenotype ( J:194590 )

♀N • spatial learning is similar to controls

decreased susceptibility to pharmacologically induced seizures ( J:194590 )

♀ • decrease in the severity of the late phase of pilocarpine induced seizures but the early phase is similar to controls

nervous system

decreased susceptibility to pharmacologically induced seizures ( J:194590 )

♀ • decrease in the severity of the late phase of pilocarpine induced seizures but the early phase is similar to controls

decreased susceptibility to neuronal excitotoxicity ( J:194590 )

♀ • marked decrease in neuronal cell death in the hippocampus following pilocarpine induced seizures

reduced long-term potentiation ( J:194590 )

♀ • decrease in the potentiation of the fEPSP slope following high-frequency stimulus at Schaffer collateral synapses in the CA1 region

cellular

decreased susceptibility to neuronal excitotoxicity ( J:194590 )

♀ • marked decrease in neuronal cell death in the hippocampus following pilocarpine induced seizures

homeostasis/metabolism

decreased susceptibility to neuronal excitotoxicity ( J:194590 )

♀ • marked decrease in neuronal cell death in the hippocampus following pilocarpine induced seizures

Genotype
MGI:5474574

ot2

• Allelic Composition: Trpc5^tm1.1Lbi/Y
• Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * CBA

behavior/neurological

behavior/neurological phenotype ( J:194590 )

♂N • spatial learning is similar to controls

decreased susceptibility to pharmacologically induced seizures ( J:194590 )

♂ • decrease in the severity of the late phase of pilocarpine induced seizures but the early phase is similar to controls

nervous system

decreased susceptibility to pharmacologically induced seizures ( J:194590 )

♂ • decrease in the severity of the late phase of pilocarpine induced seizures but the early phase is similar to controls

decreased susceptibility to neuronal excitotoxicity ( J:194590 )

♂ • marked decrease in neuronal cell death in the hippocampus following pilocarpine induced seizures

reduced long-term potentiation ( J:194590 )

♂ • decrease in the potentiation of the fEPSP slope following high-frequency stimulus at Schaffer collateral synapses in the CA1 region

cellular

decreased susceptibility to neuronal excitotoxicity ( J:194590 )

♂ • marked decrease in neuronal cell death in the hippocampus following pilocarpine induced seizures

homeostasis/metabolism

decreased susceptibility to neuronal excitotoxicity ( J:194590 )

♂ • marked decrease in neuronal cell death in the hippocampus following pilocarpine induced seizures