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Del(11Nlrp1a-Nlrp1c-ps)1Smas
Targeted Allele Detail
Nomenclature
Symbol: Del(11Nlrp1a-Nlrp1c-ps)1Smas
Name: deletion, Chr 11, Seth Masters
MGI ID: MGI:5472123
Synonyms: Nlrp1-, Nlrp1abc-/-
Gene: Del(11Nlrp1a-Nlrp1c-ps)1Smas  Location: Chr11:70983062-71176058 bp  Genetic Position: Chr11, Syntenic
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:191055
Parent Cell Line:  E14 (ES Cell)
Strain of Origin:  129P2/OlaHsd
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intergenic deletion, Intragenic deletion
  Del(11Nlrp1a-Nlrp1c-ps)1Smas involves 4 genes/genome features (Nlrp1a, Nlrp1b, Gm23266 ...) View all
 
Mutation detailsMicer plasmid MHPP282m18 was first inserted in intron 10 of Nlrp1a and Micer plasmid MHPN379g03 was then inserted in cis orientation to the first insertion about 65 kb in the telomeric direction away from Nlrp1c-ps. Transient cre expression then excised all sequence between the two loxP sites in the two insertions. This deleted the base pair region between 71,105,252 and 71,350,339 (Build 38) and removes the first 10 exons of Nlrp1a and all of Nlrp1b and Nlrp1c-ps. (J:191055)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Structures Affected by this Mutation: 1 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Del(11Nlrp1a-Nlrp1c-ps)1Smas Mutation:  1 strain or line available
References
Original:  J:191055 Masters SL, et al., NLRP1 Inflammasome Activation Induces Pyroptosis of Hematopoietic Progenitor Cells. Immunity. 2012 Dec 14;37(6):1009-23
All:  7 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
11/30/2021
MGI 6.17
The Jackson Laboratory