Uba6^tm1.1Whpr
Targeted Allele Detail

Summary

• Symbol: Uba6^tm1.1Whpr
• Name: ubiquitin-like modifier activating enzyme 6; targeted mutation 1.1, Wade Harper
• MGI ID: MGI:5470301
• Synonyms: Uba6flox
• Gene: Uba6 Location: Chr5:86258579-86320602 bp, - strand Genetic Position: Chr5, 43.56 cM
• Alliance: Uba6^tm1.1Whpr page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:198126
• Parent Cell Line: iTL BA1 (ES Cell)
• Strain of Origin: (C57BL/6NTac x 129S6/SvEvTac)F1

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: A targeting vector was designed to insert a loxP site upstream of exon 16. A second loxP site, followed by a frt-flanked neomycin resistance (neo) cassette, was inserted downstream of exon 17. Flp-mediated recombination removed the neo cassette and left exons 16 and 17 floxed. (J:198126)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Uba6 Mutation: 57 strains or lines available

References

• Original: J:198126 Lee PC, et al., Altered social behavior and neuronal development in mice lacking the Uba6-Use1 ubiquitin transfer system. Mol Cell. 2013 Apr 25;50(2):172-84
• All: 1 reference(s)