Pak1^tm1.1Xwg
Targeted Allele Detail

Summary

• Symbol: Pak1^tm1.1Xwg
• Name: p21 (RAC1) activated kinase 1; targeted mutation 1.1, Xin Wang
• MGI ID: MGI:5470058
• Synonyms: Pak1^f
• Gene: Pak1 Location: Chr7:97437748-97561588 bp, + strand Genetic Position: Chr7, 53.57 cM
• Alliance: Pak1^tm1.1Xwg page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:193804
• Parent Cell Line: R1 (ES Cell)
• Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: A loxP site was inserted upstream of exon 3. A floxed neo cassette was inserted downstream of exon 3. Cre-mediated recombination removed the neo cassette and left exon 3 floxed. (J:193804)

Expression

In Structures Affected by this Mutation:

3 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Pak1 Mutation: 36 strains or lines available

References

• Original: J:193804 Liu W, et al., Pak1 as a novel therapeutic target for antihypertrophic treatment in the heart. Circulation. 2011 Dec 13;124(24):2702-15
• All: 5 reference(s)