Rab7^tm1.1Ale
Targeted Allele Detail

Summary

• Symbol: Rab7^tm1.1Ale
• Name: RAB7, member RAS oncogene family; targeted mutation 1.1, Aimee Edinger
• MGI ID: MGI:5469733
• Synonyms: Rab7^flox
• Gene: Rab7 Location: Chr6:87976088-88022252 bp, - strand Genetic Position: Chr6, 39.13 cM
• Alliance: Rab7^tm1.1Ale page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:211733
• Parent Cell Line: R1 (ES Cell)
• Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: A targeting vector was designed to insert a single loxP site upstream of exon 1, and a loxP-flanked neomycin resistance (neo) cassette downstream of exon 1. Cre-mediated recombination removed the neo cassette and left exon floxed. (J:101977, J:211733)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Rab7 Mutation: 118 strains or lines available

References

• Original: J:211733 Roy SG, et al., Reciprocal effects of rab7 deletion in activated and neglected T cells. Autophagy. 2013 Jul;9(7):1009-23
• All: 6 reference(s)