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Allele Symbol Allele Name Allele ID |
Rab7tm1.1Ale targeted mutation 1.1, Aimee Edinger MGI:5469733 |
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| Summary |
2 genotypes
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• T cells have increased mitochondrial mass relative to wild-type
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• nutrient restricted purified naive T cells treated with cholorquine do not exhibit autophagic degradation activity (autophagic flux) in contrast to wild-type controls
• T cells are 10% larger than controls both before and after stimulation due to the accumulation of material from impairment in autophagy
• increased survival of purified unstimulated T cells during in vitro neglect assays (cultured without stimulation)
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• defect in proliferation following either antibody-mediated TCR cross-linking or allogeneic stimulation
• In vivo CD4+ T cell proliferation is decreased to 53% as compared to 68% in wild-type
• In vivo CD8+ T cell proliferation is decreased to 51% as compared to 61% in wild-type
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• T cells have increased ROS production relative to wild-type
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• T cells are 10% larger than controls both before and after stimulation
• T cells have increased mitochondrial mass relative to wild-type
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• loss of CD8 T cells is more pronounced than loss of CD4 T cells, resulting in an elevated CD4:CD8 ratio
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• absolute number of splenic T cells is reduced by 32% relative to controls
• B cell numbers are unchanged
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• increased survival of purified unstimulated T cells during in vitro neglect assays (cultured without stimulation) as compared to controls
|
|
• defect in proliferation following either antibody-mediated TCR cross-linking or allogeneic stimulation
• In vivo CD4+ T cell proliferation is decreased to 53% as compared to 68% in wild-type
• In vivo CD8+ T cell proliferation is decreased to 51% as compared to 61% in wild-type
|
|
• T cells are 10% larger than controls both before and after stimulation
• T cells have increased mitochondrial mass relative to wild-type
|
|
• loss of CD8 T cells is more pronounced than loss of CD4 T cells, resulting in an elevated CD4:CD8 ratio
|
|
• absolute number of splenic T cells is reduced by 32% relative to controls
• B cell numbers are unchanged
|
|
• increased survival of purified unstimulated T cells during in vitro neglect assays (cultured without stimulation) as compared to controls
|
|
• defect in proliferation following either antibody-mediated TCR cross-linking or allogeneic stimulation
• In vivo CD4+ T cell proliferation is decreased to 53% as compared to 68% in wild-type
• In vivo CD8+ T cell proliferation is decreased to 51% as compared to 61% in wild-type
|
|
• nutrient restricted purified naive T cells treated with cholorquine do not exhibit autophagic degradation activity (autophagic flux) in contrast to wild-type controls
• T cells are 10% larger than controls both before and after stimulation due to the accumulation of material from impairment in autophagy
• increased survival of purified unstimulated T cells during in vitro neglect assays (cultured without stimulation)
|
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 04/23/2024 MGI 6.23 |
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