Ccnd1^tm5.1Pisc
Targeted Allele Detail

Summary

• Symbol: Ccnd1^tm5.1Pisc
• Name: cyclin D1; targeted mutation 5.1, Piotr Sicinski
• MGI ID: MGI:5468336
• Synonyms: Ccnd1^F, D1^F
• Gene: Ccnd1 Location: Chr7:144483668-144493568 bp, - strand Genetic Position: Chr7, 88.92 cM
• Alliance: Ccnd1^tm5.1Pisc page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:192032
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: An FRT-flanked neo cassette with a 3' loxP site was inserted upstream of exon 2. An additional loxP site was inserted downstream of exon 3. Flp-mediated recombination removed the neo cassette and left exons 2 and 3 floxed. (J:192032)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Ccnd1 Mutation: 21 strains or lines available

References

• Original: J:192032 Choi YJ, et al., The requirement for cyclin D function in tumor maintenance. Cancer Cell. 2012 Oct 16;22(4):438-51
• All: 6 reference(s)