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Targeted Allele Detail
Symbol: Nrxn1tm3Sud
Name: neurexin I; targeted mutation 3, Thomas C Sudhof
MGI ID: MGI:5468258
Synonyms: LV1-Nrxn1-HA-tagged
Gene: Nrxn1  Location: Chr17:90033631-91093071 bp, - strand  Genetic Position: Chr17, 59.73 cM
Germline Transmission:  Earliest citation of germline transmission: J:101977
Parent Cell Line:  R1 (ES Cell)
Strain of Origin:  (129X1/SvJ x 129S1/Sv)F1-Kitl+
Allele Type:    Targeted (Conditional ready, No functional change)
Mutation:    Insertion
Mutation detailsExon 24, the last coding exon of the gene, encodes the transmembrane region of the protein as well as the cytoplasmic C-terminal. A 2xHA (hemagglutinin) tag followed by a loxP site was inserted in-frame into exon 24. A second loxP site was placed after the stop codon, immediately followed by an FRT-flanked PGK-neomycin resistance cassette. (J:101977)
View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Nrxn1 Mutation:  15 strains or lines available
Original:  J:101977 The Jackson Laboratory, Information obtained from The Jackson Laboratory, Bar Harbor, ME. Unpublished. 2005-2017;
All:  3 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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MGI 6.16
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