Myh9^tm7Rsad
Targeted Allele Detail

Summary

• Symbol: Myh9^tm7Rsad
• Name: myosin, heavy polypeptide 9, non-muscle; targeted mutation 7, Robert S Adelstein
• MGI ID: MGI:5467725
• Gene: Myh9 Location: Chr15:77644787-77726375 bp, - strand Genetic Position: Chr15, 36.81 cM
• Alliance: Myh9^tm7Rsad page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:204812
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted
• Mutation: Insertion
• Mutation details: The endogenous myosin, heavy polypeptide 9, non-muscle (Myh9) gene was modified by a codon substitution (GAC>AAT) in exon 31 that replaces aspartic acid with asparagine at amino acid position 1424, in the rod region of the protein (D1424N), and by insertion of a loxP flanked PGK-neomycin resistance cassette into the following intron. (J:175367)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Myh9 Mutation: 219 strains or lines available

References

• Original: J:175367 Zhang Y, et al., Mouse models of MYH9-related disease: mutations in nonmuscle myosin II-A. Blood. 2012;119(1):238-5
• All: 4 reference(s)