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Ifitm1tm1.1Ieg
Targeted Allele Detail
Summary
Symbol: Ifitm1tm1.1Ieg
Name: interferon induced transmembrane protein 1; targeted mutation 1.1, Institute of Experimental Genetics
MGI ID: MGI:5465441
Synonyms: Ifitm1tm1IEG
Gene: Ifitm1  Location: Chr7:140547342-140549740 bp, + strand  Genetic Position: Chr7, 86.2 cM, cytoband F5
Alliance: Ifitm1tm1.1Ieg page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:192287
Parent Cell Line:  E14 (ES Cell)
Strain of Origin:  129P2/OlaHsd
Mutation
description
Allele Type:    Targeted (Null/knockout, Reporter)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsA genomic fragment including exons 2 and 3, encompassing the entire coding region, was replaced with a lacZ cassette and floxed neo cassette via homologous recombination. The lacZ gene was inserted in frame into the first codon of the gene. Cre mediated recombination removed the neo cassette. (J:192287)
Generation of the Ifitm1tm1.1Ieg allele
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Mice Carrying this Mutation: 114 assay results
1 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation: 2 anatomical structure(s)
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Ifitm1 Mutation:  41 strains or lines available
References
Original:  J:192287 Klymiuk I, et al., In vivo functional requirement of the mouse Ifitm1 gene for germ cell development, interferon mediated immune response and somitogenesis. PLoS One. 2012;7(10):e44609
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
03/19/2024
MGI 6.23
The Jackson Laboratory