All Phenotypes Ifitm1<tm1.1Ieg> MGI Mouse

reproductive system

reproductive system phenotype ( J:192287 )

N	• both sexes are fertile and sperm motility is normal

embryo

embryo phenotype ( J:192287 )

N	• unlike in knock-down experiments, no abnormalities in somite or neural tube development are detected

skeleton

skeleton phenotype ( J:192287 )

N	• no abnormalities in vertebral morphology are detected

immune system

immune system phenotype ( J:192287 )

N	• no significant differences in leukocyte patterns in the peripheral blood or in immune response to Listeria monocytogenes infection

decreased granulocyte number ( J:192287 )

• slightly reduced frequency

decreased T cell number ( J:192287 )

• slightly reduced frequency of CD44+ T cells

increased IgE level ( J:192287 )

• trend towards increased plasma IgE levels

behavior/neurological

impaired balance ( J:192287 )

• modest reduction in rotarod latency to fall

liver/biliary system

increased liver weight ( J:192287 )

• slight increase in liver weights normalized to body weights

homeostasis/metabolism

• high variance in testosterone levels in males

• slightly decreased in females

increased oxygen consumption ( J:192287 )

• trend towards increased mean oxygen consumption in female mutant mice

hematopoietic system