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Targeted Allele Detail
Symbol: Chpftm1.2Hwat
Name: chondroitin polymerizing factor; targeted mutation 1.2, Hideto Watanabe
MGI ID: MGI:5464019
Gene: Chpf  Location: Chr1:75474569-75479307 bp, - strand  Genetic Position: Chr1, 39.14 cM
Germline Transmission:  Earliest citation of germline transmission: J:191659
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  Not Specified
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
Mutation detailsA loxP site was inserted upstream of exon 1. An FRT-flanked neo cassette with a 5' loxP site was inserted downstream of exon 1. Flp-mediated recombination removed the neo cassette and cre-mediated recombination removed exon 1. Western blot analysis confirmed the absence of protein expression in mouse embryonic fibroblasts. (J:191659)
Generation of the Chpftm1.1Hwat and Chpftm1.2Hwat alleles
View phenotypes and curated references for all genotypes (concatenated display).
In Structures Affected by this Mutation: 2 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Chpf Mutation:  5 strains or lines available
Original:  J:191659 Ogawa H, et al., Chondroitin sulfate synthase-2 is necessary for chain extension of chondroitin sulfate but not critical for skeletal development. PLoS One. 2012;7(8):e43806
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
MGI 6.15
The Jackson Laboratory