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Serpina3gtm1.1Arp
Targeted Allele Detail
Nomenclature
Symbol: Serpina3gtm1.1Arp
Name: serine (or cysteine) peptidase inhibitor, clade A, member 3G; targeted mutation 1.1, Philip Ashton-Rickardt
MGI ID: MGI:5450829
Synonyms: Serpina3gdelta, Serpina3gtm1.1Dowo
Gene: Serpina3g  Location: Chr12:104236245-104241939 bp, + strand  Genetic Position: Chr12, 53.71 cM, cytoband F1
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:189782
Parent Cell Line:  Other (see notes) (ES Cell)
Strain of Origin:  C57BL/6J
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsA loxP site was inserted upstream of exon 4. A floxed neo cassette was inserted downstream of exon 4. Cre-mediated recombination removed exon 4 and the neo cassette. Experiments confirmed the absence of transcript expression in splenocytes. (J:195889)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Serpina3g Mutation:  1 strain or line available
Notes
ES cell line = PRX-B6tN-1 (C57BL/6J).
References
Original:  J:189782 Byrne SM, et al., Cathepsin B controls the persistence of memory CD8+ T lymphocytes. J Immunol. 2012 Aug 1;189(3):1133-43
All:  2 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
05/19/2020
MGI 6.15
The Jackson Laboratory