All Phenotypes Serpina3g<tm1.1Arp> MGI Mouse

Phenotypes associated with this allele

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	\Serpina3g^tm1.1Arp/\Serpina3g^tm1.1Arp	involves: C57BL/6	MGI:5450841
cx2	\Ctsb^tm1Jde/\Ctsb^tm1Jde \Serpina3g^tm1.1Arp/\Serpina3g^tm1.1Arp	involves: 129P2/OlaHsd * C57BL/6	MGI:5450842
cx3	\Serpina3g^tm1.1Arp/\Serpina3g^tm1.1Arp \Tg(TcrLCMV)#Sdz/0	involves: C57BL/6 * DBA/2	MGI:5450844

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

immune system

decreased T cell proliferation ( J:189782 )

• of CD44^hiCD8+ T cells in the absence of antigen stimulation

• of gp33+CD8+ T cells after LCMV infection

abnormal memory T cell morphology ( J:189782 )

• contain fewer intact lysosomes

decreased CD8-positive, alpha-beta memory T cell number ( J:189782 )

• fewer memory CD44^hiCD8+ T cells with age

• beginning at 16 weeks in the blood

• at 15 weeks in the bone marrow

• after 130 days of LCMV infection in the spleen and inguinal lymph nodes

• after successive infections

abnormal response to infection ( J:189782 )

• after LCMV infection, mice exhibit fewer CD8+ memory T cells compared with wild-type mice

hematopoietic system

decreased T cell proliferation ( J:189782 )

• of CD44^hiCD8+ T cells in the absence of antigen stimulation

• of gp33+CD8+ T cells after LCMV infection

abnormal memory T cell morphology ( J:189782 )

• contain fewer intact lysosomes

decreased CD8-positive, alpha-beta memory T cell number ( J:189782 )

• fewer memory CD44^hiCD8+ T cells with age

• beginning at 16 weeks in the blood

• at 15 weeks in the bone marrow

• after 130 days of LCMV infection in the spleen and inguinal lymph nodes

• after successive infections

cellular

decreased T cell proliferation ( J:189782 )

• of CD44^hiCD8+ T cells in the absence of antigen stimulation

• of gp33+CD8+ T cells after LCMV infection

Allelic Composition	\Ctsb^tm1Jde/\Ctsb^tm1Jde \Serpina3g^tm1.1Arp/\Serpina3g^tm1.1Arp
Genetic Background	involves: 129P2/OlaHsd * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ctsb^tm1Jde mutation (3 available); any Ctsb mutation (40 available)
Serpina3g^tm1.1Arp mutation (1 available); any Serpina3g mutation (26 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

immune system

immune system phenotype ( J:189782 )

N	• unlike Serpina3g^tm1Dowo homozygotes, memory T cells exhibit normal numbers of lysosomes, restored endogenous memory phenotype CD44^hiCD8+ T cell populations and rescued LCMV-specific central CD8+ T cell population

Allelic Composition	\Serpina3g^tm1.1Arp/\Serpina3g^tm1.1Arp \Tg(TcrLCMV)#Sdz/0
Genetic Background	involves: C57BL/6 * DBA/2

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Serpina3g^tm1.1Arp mutation (1 available); any Serpina3g mutation (26 available)
Tg(TcrLCMV)#Sdz mutation (1 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

hematopoietic system

decreased T cell proliferation ( J:189782 )

• of adoptively transferred memory P14+ CD8+ T cells

immune system

decreased T cell proliferation ( J:189782 )

• of adoptively transferred memory P14+ CD8+ T cells

cellular

decreased T cell proliferation ( J:189782 )

• of adoptively transferred memory P14+ CD8+ T cells

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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