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Tg(Prnp-FUS)WT3Cshw
Transgene Detail
Nomenclature
Symbol: Tg(Prnp-FUS)WT3Cshw
Name: transgene insertion WT3, Christopher Shaw
MGI ID: MGI:5445385
Synonyms: hFUS, PrP-hFUS line WT3, PrP-hFUS-WT3
Transgene: Tg(Prnp-FUS)WT3Cshw  Location: unknown  
Transgene
origin
Strain of Origin:  (C57BL/6 x Crl:CD1(ICR))F1
Transgene
description
Transgene Type:    Transgenic (Humanized sequence, Inserted expressed sequence)
Mutation:    Insertion
 
Tg(Prnp-FUS)WT3Cshw expresses 1 gene
 
Mutation detailsThe transgene was designed to have the mouse prion protein promoter sequences (from vector MoPrp.Xho) and a human wild-type Fused in sarcoma (FUS) cDNA sequence with N-terminal hemagglutinin-tag (HA-hFUS). Three founders were established, including line WT3. (J:189360)
Phenotypes
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View phenotypes for all genotypes (concatenated display).
Disease models
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Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
References
Original:  J:189360 Mitchell JC, et al., Overexpression of human wild-type FUS causes progressive motor neuron degeneration in an age- and dose-dependent fashion. Acta Neuropathol. 2012 Sep 9;
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
04/07/2015
MGI 5.21
The Jackson Laboratory