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Kittm4.1Bsm
Targeted Allele Detail
Nomenclature
Symbol: Kittm4.1Bsm
Name: kit oncogene; targeted mutation 4.1, Peter Besmer
MGI ID: MGI:5442620
Synonyms: KitV558delta;T669I
Gene: Kit  Location: Chr5:75574916-75656722 bp, + strand  Genetic Position: Chr5, 39.55 cM
Alopecia and 'red paw' in Kittm4.1Bsm/Kit+ mice

Show the 4 phenotype image(s) involving this allele.

Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:188434
Parent Cell Line:  CJ7 (ES Cell)
Strain of Origin:  129S1/Sv-Oca2+ Tyr+ Kitl+
Mutation
description
Allele Type:    Targeted
Mutations:    Insertion, Nucleotide substitutions
 
Mutation details
Generation of the Kittm4.1Bsm/Kit+ allele containing the V558delta and T669I mutations
Phenotypes
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View phenotypes for all genotypes (concatenated display).
Disease models
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Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Kit Mutation:  109 strains or lines available
References
Original:  J:188434 Bosbach B, et al., Imatinib resistance and microcytic erythrocytosis in a KitV558Delta;T669I/+ gatekeeper-mutant mouse model of gastrointestinal stromal tumor. Proc Natl Acad Sci U S A. 2012 Aug 21;109(34):E2276-83
All:  2 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
08/12/2014
MGI 5.19
The Jackson Laboratory