Pcdhg^tm1.1Tman
Targeted Allele Detail

Summary

• Symbol: Pcdhg^tm1.1Tman
• Name: protocadherin gamma cluster; targeted mutation 1.1, Tom Maniatis
• MGI ID: MGI:5440844
• Synonyms: Pcdhg^tcko
• Gene: Pcdhg Location: unknown Genetic Position: Chr18, Syntenic

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:188341
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129S4/SvJae

Mutation description

• Allele Type: Targeted
• Mutations: Insertion, Intragenic deletion
• Mutation details: The genomic sequence encoding Pcdhgc3, Pcdhgc4 and Pcdhgc5 was replaced with a floxed construct containing a self-excising neo cassette. Cre-mediated recombination removed the neo cassette. By deleting three variable exons, this allele is a knock-out of three C-type isoforms (TCKO). (J:188341)

Expression

In Structures Affected by this Mutation:

2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Pcdhg Mutation: 12 strains or lines available

References

• Original: J:188341 Chen WV, et al., Functional significance of isoform diversification in the protocadherin gamma gene cluster. Neuron. 2012 Aug 9;75(3):402-9
• All: 2 reference(s)