Crim1^tm1.1Dpen
Targeted Allele Detail

Summary

• Symbol: Crim1^tm1.1Dpen
• Name: cysteine rich transmembrane BMP regulator 1; targeted mutation 1.1, David J Pennisi
• MGI ID: MGI:5438615
• Synonyms: Crim1^deltaFLOX
• Gene: Crim1 Location: Chr17:78507677-78684021 bp, + strand Genetic Position: Chr17, 48.09 cM
• Alliance: Crim1^tm1.1Dpen page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:187855
• Parent Cell Line: E14 (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Cre-mediataed recombination removed exons 3 and 4. The FRT-flanked neo cassette remains intact. Immunohistochemistry confirmed the absence of protein expression in the kidney at E16. (J:187855)

Expression

In Structures Affected by this Mutation:

3 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Crim1 Mutation: 51 strains or lines available

References

• Original: J:187855 Chiu HS, et al., Production of a mouse line with a conditional Crim1 mutant allele. Genesis. 2012 Sep;50(9):711-6
• All: 3 reference(s)