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Elmod1rda-2J
Spontaneous Allele Detail
Nomenclature
Symbol: Elmod1rda-2J
Name: ELMO/CED-12 domain containing 1; roundabout 2 Jackson
MGI ID: MGI:5437446
Gene: Elmod1  Location: Chr9:53818741-53882585 bp, - strand  Genetic Position: Chr9, 29.35 cM
Cochlear hair cell abnormalities in rda/rda and Elmod1rda-2J/Elmod1rda-2J mice

Show the 2 phenotype image(s) involving this allele.

Mutation
origin
Strain of Origin:  B10.BR-H2k2 H2-T18a/SgSnJ
Mutation
description
Allele Type:    Spontaneous (Null/knockout)
Mutation:    Duplication
  Elmod1rda-2J involves 1 genes/genome features (Elmod1) View all
 
Mutation detailsA spontaneous mutation results in a 606 bp intragenic duplication of exons 3 through 8. Western blot analysis confirmed the absence of a 62 kDa protein compared with the wild-type 36 kDa. (J:187273)
Molecular structure of the Elmod1rda-2J mutation
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Mice Carrying this Mutation: 5 assay results
In Structures Affected by this Mutation: 2 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Elmod1 Mutation:  25 strains or lines available
References
Original:  J:187273 Johnson KR, et al., Mutations of the mouse ELMO domain containing 1 gene (Elmod1) link small GTPase signaling to actin cytoskeleton dynamics in hair cell stereocilia. PLoS One. 2012;7(4):e36074
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
11/16/2021
MGI 6.17
The Jackson Laboratory