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Dock8tm1Ysfk
Targeted Allele Detail
Nomenclature
Symbol: Dock8tm1Ysfk
Name: dedicator of cytokinesis 8; targeted mutation 1, Yoshinori Fukui
MGI ID: MGI:5437274
Gene: Dock8  Location: Chr19:24999529-25202432 bp, + strand  Genetic Position: Chr19, 19.91 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:185165
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  Not Specified
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsA neo cassette replaced exons 3 and 4. Western blot confirmed the absence of protein expression in spleen cell lysates. (J:185165)
Phenotypes
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View phenotypes for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Dock8 Mutation:  4 strains or lines available
References
Original:  J:185165 Harada Y, et al., DOCK8 is a Cdc42 activator critical for interstitial dendritic cell migration during immune responses. Blood. 2012 May 10;119(19):4451-61
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
03/17/2015
MGI 5.21
The Jackson Laboratory