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Targeted Allele Detail
Symbol: Pink1tm1.1Wrst
Name: PTEN induced putative kinase 1; targeted mutation 1.1, Wolfgang Wurst
MGI ID: MGI:5436308
Synonyms: Pink1-
Gene: Pink1  Location: Chr4:138313409-138326296 bp, - strand  Genetic Position: Chr4, 70.14 cM
Germline Transmission:  Earliest citation of germline transmission: J:183290
Parent Cell Line:  TBV2 (ES Cell)
Strain of Origin:  129S2/SvPas
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
Mutation detailsA loxP site and FRt flanked neo cassette were inserted upstream of exon 2 and a loxP site was inserted downstream of exon 3 via homologous recombination. Recombinase mediated recombination removed the neo cassette and exons 2 and 3. RT-PCR analysis indicates a dramatic reduction in mRNA expression in homozygous mice. (J:183290)
View phenotypes and curated references for all genotypes (concatenated display).
Disease models
In Structures Affected by this Mutation: 1 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Pink1 Mutation:  9 strains or lines available
Original:  J:183290 Glasl L, et al., Pink1-deficiency in mice impairs gait, olfaction and serotonergic innervation of the olfactory bulb. Exp Neurol. 2012 May;235(1):214-27
All:  5 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
MGI 6.16
The Jackson Laboratory