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b2b1660Clo
Chemically induced Allele Detail
Nomenclature
Symbol: b2b1660Clo
Name: Mutant line 1660; Bench to Bassinet Program (B2B/CVDC), mutation 1660 Cecilia Lo
MGI ID: MGI:5433323
Synonyms: Pistachio
Gene: b2b1660Clo  Location: unknown  Genetic Position: ChrUN, Syntenic
Mutant 11660-002-LA exhibits dextrocardia with situs inversus and possible bile duct obstruction

Show the 20 image(s) involving this allele.

Mutation
origin
Strain of Origin:  C57BL/6J
Mutation
description
Allele Type:    Chemically induced (ENU)
Mutation:    Undefined
    This ENU-induced mutation was isolated in a screen at the University of Pittsburgh. (J:175213)
Phenotypes
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View phenotypes for all genotypes (concatenated display).
Disease models
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Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any b2b1660Clo Mutation:  1 strain or line available
Notes
Summative Diagnosis:
Laterality defect phenotypes: Heterotaxy and situs inversus totalis with left pulmonary isomerism, hypoplastic spleen/asplenia, abnormal bilateral inferior vena cava (IVC)
Noncardiac phenotype: Malaligned sternovertebrae, dyskinetic/immotile respiratory cilia

Phenotypic Similarity to Human Syndrome: Primary ciliary dyskinesia, Kartagener's syndrome, Heterotaxy

Fyler Codes
The Fyler code developed by The Boston Children's Heart Foundation in Boston Children's Hospital provides a hierarchical clinical diagnosis of congenital cardiovascular defects and other disorders. These codes are used to delineate pathology in the mutant mouse models that parallel human disease and can be cross referenced to the International Pediatric and Congenital Cardiac Code (IPCCC) (http://www.ipccc.net/).

Fyler Code ID Code Description
0190 Heterotaxy Syndrome
2810 Inferior vena cava anomaly

References
Original:  J:175213 Lo C, Information submitted by the NHLBI Cardiovascular Development Consortium (CvDC), Bench to Bassinet Program. MGI Direct Data Submission (B2B/CvDC). 2011-13;
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
04/15/2014
MGI 5.17
The Jackson Laboratory