Tmem100tm1.1Ysai
Targeted Allele Detail
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Symbol: |
Tmem100tm1.1Ysai |
Name: |
transmembrane protein 100; targeted mutation 1.1, Yoshihiko Saito |
MGI ID: |
MGI:5432904 |
Synonyms: |
Tmem100-lacZ |
Gene: |
Tmem100 Location: Chr11:89921174-89927334 bp, + strand Genetic Position: Chr11, 54.75 cM
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Alliance: |
Tmem100tm1.1Ysai page
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Abnormal cardiac morphology, pericardial effusion, and growth retardation in Tmem100tm1.1Ysai and Acvrl1tm1Dgen homozygotes
Show the 4 phenotype image(s) involving this allele.
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Germline Transmission: |
Earliest citation of germline transmission:
J:186473
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Parent Cell Line: |
Not Specified (ES Cell)
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Strain of Origin: |
C57BL/6
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Allele Type: |
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Targeted (Null/knockout, Reporter) |
Mutations: |
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Insertion, Intragenic deletion
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Mutation details: Exon 3 which includes the entire coding sequence was replaced with a lacZ gene and floxed neo cassette. Cre mediated recombination removed the neo cassette.
(J:186473)
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Generation of the Tmem100tm1.1Ysai allele |
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View phenotypes and curated references for all genotypes (concatenated display).
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Mouse strains and cell lines
available from the International Mouse Strain Resource
(IMSR) |
Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available
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Carrying any Tmem100 Mutation: |
15 strains or lines available
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Original: |
J:186473 Somekawa S, et al., Tmem100, an ALK1 receptor signaling-dependent gene essential for arterial endothelium differentiation and vascular morphogenesis. Proc Natl Acad Sci U S A. 2012 Jul 24;109(30):12064-9 |
All: |
2 reference(s) |
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