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Targeted Allele Detail
Symbol: Tmem100tm1.1Ysai
Name: transmembrane protein 100; targeted mutation 1.1, Yoshihiko Saito
MGI ID: MGI:5432904
Synonyms: Tmem100-lacZ
Gene: Tmem100  Location: Chr11:90030348-90036508 bp, + strand  Genetic Position: Chr11, 54.75 cM
Abnormal cardiac morphology, pericardial effusion, and growth retardation in Tmem100tm1.1Ysai and Acvrl1tm1Dgen homozygotes

Show the 4 phenotype image(s) involving this allele.

Germline Transmission:  Earliest citation of germline transmission: J:186473
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  C57BL/6
Allele Type:    Targeted (Null/knockout, Reporter)
Mutations:    Insertion, Intragenic deletion
Mutation detailsExon 3 which includes the entire coding sequence was replaced with a lacZ gene and floxed neo cassette. Cre mediated recombination removed the neo cassette. (J:186473)
Generation of the Tmem100tm1.1Ysai allele
View phenotypes for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Tmem100 Mutation:  4 strains or lines available
Original:  J:186473 Somekawa S, et al., Tmem100, an ALK1 receptor signaling-dependent gene essential for arterial endothelium differentiation and vascular morphogenesis. Proc Natl Acad Sci U S A. 2012 Jul 24;109(30):12064-9
All:  2 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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MGI 6.01
The Jackson Laboratory