Analysis Tools
mortality/aging
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• die around E10.5 - E11.0
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cardiovascular system
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• at E9.5, one of the paired dorsal aortas often shows marked dilation with a narrowing or closure at the opposite end and clumps of blood cells are frequently seen in the caudal region
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• expression analysis indicates defects in arterial differentiation and maturation
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• mural layers surrounding the aorta are thinner at E9.5
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• coarse vascular patterns indicative of impaired remodeling are seen at E9.5
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• absence of large vessels at E10.5
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• from the dorsal aorta towards the sinus venosus
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• at E10.5
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• mural layers surrounding the myocardium are thinner at E9.5
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• poorly formed at E9.5
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• at E9.5
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• massive pericardial effusion at E10.5
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• decrease in vitelline circulation at E9.0 - E9.5
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embryo
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• absence of large vessels at E10.5
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• at E10.5
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• detachment of endodermal and mesodermal layers at E9.5
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• coarse vascular patterns indicative of impaired remodeling are seen at E9.5
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growth/size/body
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• at E9.5
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• at E10.5
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homeostasis/metabolism
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• massive pericardial effusion at E10.5
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muscle
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• poorly formed at E9.5
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