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Fblim1tm1.1Chen
Targeted Allele Detail
Nomenclature
Symbol: Fblim1tm1.1Chen
Name: filamin binding LIM protein 1; targeted mutation 1.1, Ju Chen
MGI ID: MGI:5432800
Gene: Fblim1  Location: Chr4:141576062-141606052 bp, - strand  Genetic Position: Chr4, 74.64 cM, cytoband E1
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:186501
Parent Cell Line:  R1 (ES Cell)
Strain of Origin:  (129X1/SvJ x 129S1/Sv)F1-Kitl+
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsA loxP site was inserted upstream of exon 7. An FRT-flanked neo cassette with a 5' loxP site was inserted downstream of exon 7. Cre mediated recombination removed exon 7 and left the neo cassette intact. Western blot analysis confirmed the absence of protein expression in bone marrow derived stromal cells. (J:186501)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Structures Affected by this Mutation: 2 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Fblim1 Mutation:  77 strains or lines available
References
Original:  J:186501 Xiao G, et al., Critical role of filamin-binding LIM protein 1 (FBLP-1)/migfilin in regulation of bone remodeling. J Biol Chem. 2012 Jun 15;287(25):21450-60
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
11/26/2019
MGI 6.14
The Jackson Laboratory