Fblim1^tm1.1Chen
Targeted Allele Detail

Summary

• Symbol: Fblim1^tm1.1Chen
• Name: filamin binding LIM protein 1; targeted mutation 1.1, Ju Chen
• MGI ID: MGI:5432800
• Gene: Fblim1 Location: Chr4:141303373-141333351 bp, - strand Genetic Position: Chr4, 74.64 cM, cytoband E1
• Alliance: Fblim1^tm1.1Chen page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:186501
• Parent Cell Line: R1 (ES Cell)
• Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A loxP site was inserted upstream of exon 7. An FRT-flanked neo cassette with a 5' loxP site was inserted downstream of exon 7. Cre mediated recombination removed exon 7 and left the neo cassette intact. Western blot analysis confirmed the absence of protein expression in bone marrow derived stromal cells. (J:186501)

Expression

In Structures Affected by this Mutation:

2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Fblim1 Mutation: 82 strains or lines available

References

• Original: J:186501 Xiao G, et al., Critical role of filamin-binding LIM protein 1 (FBLP-1)/migfilin in regulation of bone remodeling. J Biol Chem. 2012 Jun 15;287(25):21450-60
• All: 1 reference(s)