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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Fblim1tm1.1Chen
targeted mutation 1.1, Ju Chen
MGI:5432800
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Fblim1tm1.1Chen/Fblim1tm1.1Chen involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ MGI:5432803


Genotype
MGI:5432803
hm1
Allelic
Composition		 Fblim1tm1.1Chen/Fblim1tm1.1Chen
Genetic
Background		 involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Fblim1tm1.1Chen mutation (0 available); any Fblim1 mutation (82 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
skeleton
abnormal osteoblast differentiation ( J:186501 )
• mice exhibit reduced bone marrow derived stromal cells growth and survival, decreased osteoblast progenitors and inhibited osteoblast differentiation compared with wild-type mice
abnormal osteoclast differentiation ( J:186501 )
• mice exhibit increased osteoclast differentiation compared with wild-type mice
increased osteoclast cell number ( J:186501 )
• with increased primary and secondary spongiosa
abnormal osteoclast physiology ( J:186501 )
• mice exhibit increased osteoclast activity compared with wild-type mice
abnormal trabecular bone morphology ( J:186501 )
• increased trabecular space

cellular
increased apoptosis ( J:186501 )
• of bone marrow derived stromal cells
abnormal osteoblast differentiation ( J:186501 )
• mice exhibit reduced bone marrow derived stromal cells growth and survival, decreased osteoblast progenitors and inhibited osteoblast differentiation compared with wild-type mice
abnormal osteoclast differentiation ( J:186501 )
• mice exhibit increased osteoclast differentiation compared with wild-type mice
decreased cell proliferation ( J:186501 )
• of bone marrow derived stromal cells

immune system
abnormal osteoclast differentiation ( J:186501 )
• mice exhibit increased osteoclast differentiation compared with wild-type mice
increased osteoclast cell number ( J:186501 )
• with increased primary and secondary spongiosa
abnormal osteoclast physiology ( J:186501 )
• mice exhibit increased osteoclast activity compared with wild-type mice

hematopoietic system
abnormal osteoclast differentiation ( J:186501 )
• mice exhibit increased osteoclast differentiation compared with wild-type mice
increased osteoclast cell number ( J:186501 )
• with increased primary and secondary spongiosa
abnormal osteoclast physiology ( J:186501 )
• mice exhibit increased osteoclast activity compared with wild-type mice




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
09/30/2025
MGI 6.24 		The Jackson Laboratory