Nxnl1^tm1.1Tlev
Targeted Allele Detail

Summary

• Symbol: Nxnl1^tm1.1Tlev
• Name: nucleoredoxin-like 1; targeted mutation 1.1, Thierry Leveillard
• MGI ID: MGI:5432156
• Gene: Nxnl1 Location: Chr8:72013199-72019245 bp, - strand Genetic Position: Chr8, 34.43 cM
• Alliance: Nxnl1^tm1.1Tlev page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:186370
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: BALB/c

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: A loxP site was inserted upstream of exon 1. An FRT flanked neo cassette with a 5' losP site was inserted downstream of exon 1. FLP mediated recombination removed the neo cassette. Cre mediated recombination removed exon 1. (J:186370)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Nxnl1 Mutation: 10 strains or lines available

References

• Original: J:186370 Cronin T, et al., The disruption of the rod-derived cone viability gene leads to photoreceptor dysfunction and susceptibility to oxidative stress. Cell Death Differ. 2010 Jul;17(7):1199-210
• All: 2 reference(s)