Tg(HLA-DRA,HLA-DRB1*0405)1Jic
Transgene Detail

Summary

• Symbol: Tg(HLA-DRA,HLA-DRB1*0405)1Jic
• Name: transgene insertion 1, Central Institute for Experimental Animals (CIEA), Japan
• MGI ID: MGI:5431522
• Synonyms: HLA-DR4
• Transgene: Tg(HLA-DRA,HLA-DRB1*0405)1Jic Location: unknown
• Alliance: Tg(HLA-DRA,HLA-DRB1*0405)1Jic page

Transgene origin

• Strain of Origin: (NOD/Shi x NOD.Cg-Prkdc^scid Il2rg^tm1Sug/Jic)F1

Transgene description

• Transgene Type: Transgenic (Inserted expressed sequence)
• Mutation: Insertion
• Tg(HLA-DRA,HLA-DRB1*0405)1Jic expresses 1 gene
  Transgene expresses:
  

  Organism

  Expressed Gene

  Homolog in Mouse

  Note

  human

  HLA-DRA (3122)

  H2-Ea

  (MGI:95900)

• Mutation details: Mouse fertilized oocytes were microinjected with transgene constructs in which the human MHC class II genes HLA-DRA and HLA-DRB1*0405, whose protein products together constitute HLA-DR4, reside downstream of the promoter region (nt -2172 to +12) of the mouse MHC class II Ea gene. The HLA coding sequence, in each case, is inserted into a ~1200 bp segment of the rabbit beta-globin gene which provides an intron, 3'-untranslated region (3'-UTR) and polyadenylation signal. (J:182727, J:186300)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available

References

• Original: J:182727 Suzuki M, et al., Induction of human humoral immune responses in a novel HLA-DR-expressing transgenic NOD/Shi-scid/gammacnull mouse. Int Immunol. 2012 Apr;24(4):243-52
• All: 2 reference(s)