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Targeted Allele Detail
Symbol: Arhgap33tm1.1Wbm
Name: Rho GTPase activating protein 33; targeted mutation 1.1, Walter Birchmeier
MGI ID: MGI:5431233
Gene: Arhgap33  Location: Chr7:30522226-30535060 bp, - strand  Genetic Position: Chr7, 18.43 cM
Germline Transmission:  Earliest citation of germline transmission: J:185948
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  Not Specified
Allele Type:    Targeted (Null/knockout, Reporter)
Mutations:    Insertion, Intragenic deletion
Mutation detailsExons 7 - 12 were replaced with a lacZ gene with a nuclear localization signal and a self-excising neo cassette via homologous recombination. Western blot and immunoprecipitation analyses confirmed the absence of protein expression in cortical lysates from homozygous mice. LacZ expression is seen in the nervous system. (J:185948)
View phenotypes for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Arhgap33 Mutation:  13 strains or lines available
Original:  J:185948 Rosario M, et al., Neocortical dendritic complexity is controlled during development by NOMA-GAP-dependent inhibition of Cdc42 and activation of cofilin. Genes Dev. 2012 Aug 1;26(15):1743-57
All:  1 reference(s)

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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
MGI 6.03
The Jackson Laboratory