Arhgap33^tm1.1Wbm
Targeted Allele Detail

Summary

• Symbol: Arhgap33^tm1.1Wbm
• Name: Rho GTPase activating protein 33; targeted mutation 1.1, Walter Birchmeier
• MGI ID: MGI:5431233
• Gene: Arhgap33 Location: Chr7:30221651-30234485 bp, - strand Genetic Position: Chr7, 18.43 cM
• Alliance: Arhgap33^tm1.1Wbm page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:185948
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Null/knockout, Reporter)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Exons 7 - 12 were replaced with a lacZ gene with a nuclear localization signal and a self-excising neo cassette via homologous recombination. Western blot and immunoprecipitation analyses confirmed the absence of protein expression in cortical lysates from homozygous mice. LacZ expression is seen in the nervous system. (J:185948)

Expression

In Structures Affected by this Mutation:

6 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Arhgap33 Mutation: 45 strains or lines available

References

• Original: J:185948 Rosario M, et al., Neocortical dendritic complexity is controlled during development by NOMA-GAP-dependent inhibition of Cdc42 and activation of cofilin. Genes Dev. 2012 Aug 1;26(15):1743-57
• All: 1 reference(s)