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Gt(ROSA)26Sortm1(tTA,tetO-Mir155)Fjsl
Targeted Allele Detail
Nomenclature
Symbol: Gt(ROSA)26Sortm1(tTA,tetO-Mir155)Fjsl
Name: gene trap ROSA 26, Philippe Soriano; targeted mutation 1, Frank J Slack
MGI ID: MGI:5431136
Synonyms: Gt(ROSA)26Sortm1(tetO-Mir155)Fjsl, mir-155LSLtTA
Gene: Gt(ROSA)26Sor  Location: Chr6:113067428-113077244 bp, - strand  Genetic Position: Chr6, 52.73 cM
Gt(ROSA)26Sortm1(tTA,tetO-Mir155)Fjsl/Gt(ROSA)26Sor+ Tg(Nes-cre)1Wmz/0 mice develop disseminated lymphoma

Show the 3 phenotype image(s) involving this allele.

Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:185598
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  (C57BL/6J x SJL/J)F2
Mutation
description
Allele Type:    Targeted (Conditional ready, Inducible, Inserted expressed sequence, Transactivator)
Mutation:    Insertion
 
Gt(ROSA)26Sortm1(tTA,tetO-Mir155)Fjsl expresses 1 gene
 
Mutation detailsA construct was inserted into the locus that contained the following elements (5' to 3'): the tetracycline transactivator (tTA), two poly-adenylation sequences, the tetracycline operator with minimal CMV promoter, a floxed neo cassette with 4 poly-adenylation sequences, the mouse transcript, and a poly-adenylation sequence. The locus promoter drives expression of tTA while the tet operator drives expression of the transcript only after cre mediated removal of the floxed neo-STOP cassette that can be repressed by doxycycline treatment. (J:185598)
Schematic of the Gt(ROSA)26Sortm1(tTA,tetO-Mir155)Fjsl allele
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Disease models
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Expression
In Structures Affected by this Mutation: 6 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Gt(ROSA)26Sor Mutation:  572 strains or lines available
References
Original:  J:185598 Babar IA, et al., Nanoparticle-based therapy in an in vivo microRNA-155 (miR-155)-dependent mouse model of lymphoma. Proc Natl Acad Sci U S A. 2012 Jun 26;109(26):E1695-704
All:  3 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
04/06/2021
MGI 6.16
The Jackson Laboratory