Tg(GFAP-Fig4)#Mm
Transgene Detail

Summary

• Symbol: Tg(GFAP-Fig4)#Mm
• Name: transgene insertion, Miriam H Meisler
• MGI ID: MGI:5431007
• Transgene: Tg(GFAP-Fig4)#Mm Location: unknown
• Alliance: Tg(GFAP-Fig4)#Mm page

Transgene origin

• Strain of Origin: (C57BL/6 x SJL)F2

Transgene description

• Transgene Type: Transgenic (Inserted expressed sequence)
• Mutation: Insertion
• Tg(GFAP-Fig4)#Mm expresses 1 gene
  Transgene expresses:
  

  Organism	Expressed Gene	Note
  mouse	Fig4 (MGI:2143585)

• Mutation details: The human GFAP promoter composed of 2.2 kb of upstream sequence ant 46 bp of exon 1 in which the ATG start sequence was mutated to TTG wis used to drive expression of a mouse Fig4 cDNA. (J:185989)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available

References

• Original: J:185989 Ferguson CJ, et al., Neuronal expression of Fig4 is both necessary and sufficient to prevent spongiform neurodegeneration. Hum Mol Genet. 2012 Aug 15;21(16):3525-34
• All: 1 reference(s)