Phenotypes associated with this allele

• Allele Symbol: Tg(GFAP-Fig4)#Mm
• Allele Name: transgene insertion, Miriam H Meisler
• Allele ID: MGI:5431007
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
cx1	Fig4^plt1/Fig4^plt1 Tg(GFAP-Fig4)#Mm/?	involves: 129P2/OlaHsd * C3H * C57BL/6 * CAST/Ei * SJL	MGI:5431085

Genotype
MGI:5431085

cx1

• Allelic Composition: Fig4^plt1/Fig4^plt1; Tg(GFAP-Fig4)#Mm/?
• Genetic Background: involves: 129P2/OlaHsd * C3H * C57BL/6 * CAST/Ei * SJL

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

premature death ( J:185989 )

• survival not corrected relative to Fig4^plt1 homozygotes

growth/size/body

abnormal postnatal growth ( J:185989 )

• growth not corrected relative to Fig4^plt1 homozygotes

behavior/neurological

abnormal motor capabilities/coordination/movement ( J:185989 )

• severe movement disorder by 30 days of age

tremors ( J:185989 )

• by 30 days of age

nervous system

nervous system phenotype ( J:185989 )

N • astrogliosis mostly corrected

spongiform encephalopathy ( J:185989 )

• extensive

demyelination ( J:185989 )

• reduced sciatic nerve myelination

• low abundance of myelin basic protein